Sustainable amine production through hydrogenation of amides under mild conditions
Amines are vital in nature; for example, amino acids – the building blocks of proteins and thus fundamental to life – are amines. Numerous materials including pharmaceuticals, dyes, polymers, and solvents are amines. Thus, amines are important targets in chemical synthesis. The formation of amines from amides is of great interest. There are numerous amides that are widely available and inexpensive, making them attractive substrates for conversion to amines. However, amides are very stable, which makes their conversion to amines difficult. Typical approaches to convert amides to amines require metal reagents, which generate metal waste, or have poor efficiency.
Direct formation of amines from amides through hydrogenation is desirable because water should be the only by-product. However, harsh conditions are required for this conversion. The development of catalysts that allow the amide hydrogenation reaction to be performed under mild conditions is a goal of numerous chemists because it is important for sustainable pharmaceutical production.
https://xissufotoday.space/2017/07/sustainable-amine-production-through-hydrogenation-of-amides/
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