Hide and Stick
Urinary tract infections (UTIs) make life miserable for millions of people – mostly women – every year. More than half of women will have a UTI at some point in their life and although the infection can be treated with antibiotics, it often comes back. In the worst cases, UTIs become chronic and very difficult to treat effectively, although it’s not exactly clear why this happens. By studying the way that two different UTI-causing bacteria affect the cells that make up the lining of the bladder in mice (highlighted green and red), researchers think they have found an explanation. They’re discovered that the bugs responsible for chronic infections can engineer the cells in the bladder to make a cosy hiding place where the immune system can’t find them, leading to persistent UTIs that are resistant to antibiotics – an important insight that could lead to new ideas for preventing and treating chronic infections.
Written by Kat Arney
- Image from work by Valerie P. O’Brien and colleagues, Washington University School of Medicine
- Department of Molecular Microbiology and Center for Women’s Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA
- Originally published under a Creative Commons Licence (BY 4.0)
- Published in PLOS Pathogens, December 2018
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