Clear Headed Preserved for years in hospitals and labs, human…

Clear Headed

Preserved for years in hospitals and labs, human brain samples may contain valuable clues to how neurons connect to each other, or go awry in disease. Yet their secrets are often hidden among cloudy fatty molecules. This thumbnail-sized piece of human cerebellum has been bathing in a newly-developed ‘clearing’ solution – a cocktail of chemicals that sluices away fats and other obstructive particles. Similar solutions have already turned rodent brains transparent, but scientists have only just cracked the right mixture for human brains. Pictured under a microscope, a coloured stain highlights neurofilaments – stringy proteins found in the cytoplasm of neurons, each colour-coded by its depth in the tissue. The technique can be used with archived tissue samples around the world, but also with brains donated to medical science – so researchers can compare diseased and healthy tissue for clues to illnesses and insight into brain injuries.

Written by John Ankers

• Image from work by Hei Ming Lai, Alan King Lun Liu and Harry Ho Man Ng, and colleagues


• Neuropathology Unit, Division of Brain Sciences, Imperial College London and School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong


• Image originally published under a Creative Commons Licence (BY 4.0)


• Published in Nature Communications, March 2018

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